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Catalog Portfolio 2018

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Baeyer-Villiger monooxygenases (BVMOs) are flavoenzymes and belong to the the class of oxidoreductases. They catalyse the oxidation of linear, cyclic and aromatic ketones to the corresponding esters or lactones, highly similar to the chemical Baeyer-Villiger oxidation. During the enzymatic oxidation one atom of molecular oxygen is incorporated into a carbon-carbon bond of a non-activated ketone.

The figure shows the general reaction scheme of BVMO
General reaction scheme of BVMO

Besides that they are also capable of other oxidations. For example they can oxidise several heteroatoms. Depending on the structure of the substrate the might even prefer the "side reaction" over the Baeyer-Villiger oxidation.

The figure shows examples of BVMO-catalyzed oxidations on heteroatoms
examples for BVMO-catalysed "side reactions" (R are unspecified different residues)

The BVMOs in our catalog require NADPH as cofactor and accept a variety of different substrate groups. We also offer thermostable BVMOs.

/ The figure shows the different BVMO types according to the accepted substrate groups
BVMO-Types offered by Enzymical AG