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Catalog Portfolio 2019

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Halo­hydrin de­halo­genases (HD­H­Hs) are bac­teri­al en­zymes that are be­long to the class of ly­ases (EC 4.5.1.-) and which have nat­ur­ally in­volved in the min­er­al­iz­a­tion of halo­gen­ated xen­o­bi­ot­ics. They ex­hib­it high re­gio- and en­an­ti­ose­lectiv­ity to­wards aliphat­ic and aro­mat­ic sub­strates, and thus are use­ful tools for the pro­duc­tion of en­an­tiop­ure ep­ox­ides as well as their ring-open­ing products. The di­versity of non­hal­ide nuc­le­o­philes which can be used for the open­ing of ep­ox­ide rings fur­ther ex­pands their syn­thet­ic ap­plic­a­tion.

The figure shows application examples of HHDAs in the synthesis for the preparation of enantioselective epoxides as well as their ring opening products.

Synthetic application of HHDHs

Ex­amples of rel­ev­ant HHDH ap­plic­a­tions are the pro­duc­tion of op­tic­ally pure C3 or C4 fine chem­ic­al pre­curs­ors, in­clud­ing the multi-ton scale pro­duc­tion of en­an­tiop­ure (R)-4-cy­ano-3-hy­droxy­bu­tyr­ate es­ters for stat­in drugs, or the pro­duc­tion of chir­al ter­tiary al­co­hols for which con­ven­tion­al or­gan­ic syn­thes­is is rather chal­len­ging.

The photo shows the 'Ready to use' screening kit for HHDHs
HHDH Screening Kit in a ready to use format